Endocrine Abstracts

The ‘coupling’ concept of bone resorption and formation was developed at both the whole-body and microscopic levels in the 1960’s. At the whole-body level, ‘coupling’ served to explain a positive correlation observed between whole body rates of bone resorption and formation, as determined by radiocalcium kinetics. At the microscopic level, ‘coupling’ describes sequential bone remodeling at each basic multicellular unit (BMU), in which bone re...